Recent developments in human immunodeficiency virus-1 latency research
نویسندگان
چکیده
منابع مشابه
Recent developments in human immunodeficiency virus-1 latency research
Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-1) remains incurable and the virus persists due to reservoirs of latently infected CD4(+) memory T-cells and sanctuary sites within the infected individual where drug penetration is poor. Reactivating latent viruses has been a key strategy to completely eliminate the virus from the host, but many...
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The persistence of human immunodeficiency virus type 1 (HIV-1) in latent reservoirs is a major barrier to HIV cure. Reservoir establishment depends on low viral expression that may be related to provirus integration sites (IS). In vitro, in cell lines and primary T cells, latency is associated with specific IS through reduced viral expression mediated by transcriptional interference by host cel...
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1.1.1 Taxonomy The human immunodeficiency virus type 1 (HIV-1) was first isolated in 1983 (BarréSinoussi et al., 1983; Gallo et al., 1983), and firmly associated with the acquired immunodeficiency syndrome (AIDS) in 1984 (Gallo et al., 1984; Montagnier et al., 1984). A second related virus, called HIV-2, was subsequently discovered in West Africa (Clavel et al., 1986). HIV-1 and HIV-2 belong to...
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Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-8 could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV and HHV-8 in saliva specimens obtained from HIV-1 infected Iranian individuals under the Highly Active Antiviral Therapy (HAAR...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2013
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.049296-0